Pterostilbene Supreme/ Anti Oxidant

Pterostilbene Supreme, by Douglas
Laboratories, provides pterostilbene, a
methylated resveratrol that is naturally occurring
in berries. This formula also contains
resveratrol, curcumin and vitamin D3 which can
function synergistically with ptersostilbene to
support healthy aging. †
Pterostilbene, a methylated form of resveratrol is
considered the next generation of resveratrol.
Pterostilbene has advantages over resveratrol:
superior biological activity, better oral
bioavailability, and slower metabolism in the
pTeroPureTM pterostilbene is a nature identical
form of trans-pterostilbene, a stilbene found in
certain berries. The enhanced activity of
pterostilbene compared to resveratrol may, in
part, be explained by structural differences.
Pterostilbene with two methoxy groups and one
hydroxyl group has greater lipophilicity and a
higher potential for cellular uptake than
resveratrol, which has three hydroxyl groups.
Pterostilbene showed strong inhibitory activity,
much more than resveratrol, against a particular
form of cytochrome P450.
Researchers have suggested that these two
compounds also work synergistically,
supporting the theory that a combination of
pterostilbene and resveratrol in a formulation
may be more effective than using these
ingredients separately. Both pterostilbene and
resveratrol support mitochondrial function and
healthy aging by activating SIRT1, one of the
key enzymes of the sirtuin family. Sirtuins, a
class of proteins, have been implicated in
influencing aging and regulating transcription,
apoptosis and stress resistance, as well as energy
efficiency and alertness during low-calorie
situations. † Pterostilbene also supports
cardiovascular health; results from in vitro
studies showed that pterostilbene acts as a
PPARR agonist and may be a more effective
PPARR agonist and hypolipidemic agent than
resveratrol. In vivo studies demonstrate that
pterostilbene possesses lipid and glucose
lowering effects. † Pterostilbene Supreme also
contains ResvidaTM, a pure resveratrol clinically
studied for its safety. ResvidaTM resveratrol is
unique as it is not a plant extract and is not
derived from plant sources, therefore presents no
risk for contamination with pesticides and other
potentially unwanted compounds. Studies
indicate resveratrol may be supportive in
maintaining the normal aging process by helping
to prevent free radical damage that can lead to
premature aging of cells. †
Studies have shown that curcumin, a naturally
occurring group of compounds from turmeric,
function as powerful antioxidants and can help
support neurological and cardiovascular
function.† Since curcumin exhibits poor oral
absorption in the body, Douglas Labs has chosen
a highly bioavailable curcumin called
MERIVA®. Pharmacokinetic comparison
studies have shown MERIVA® to have up to a
20-fold improvement in bioavailability versus
the standard 95% turmeric extracts due to
proprietary PHYTOSOME technology which
increases hydrolytic stability.
Vitamin D, curcumin and
resveratrol/pterostilbene share many common
targets and points of overlap in gene regulation,
signal transduction and therapeutic effects. The
nature of this overlap suggests synergy upon
combination, potentially leading to an influence
on inflammatory and cardio-protective
Japanese wasabi with a specially standardized
broccoli sprout concentrate and organic
pomegranate extract are added to this formula to
support the body’s natural antioxidant and
detoxification processes. † Sulforaphane, an ITC
found in broccoli, has been found to
significantly increase the activity of
detoxification enzymes (cytochrome P450).
Pterostilbene Supreme may be a useful
supplement for individuals wishing to consume
a powerful combination of antioxidants and
vitamin D for cardiovascular health or longevity
FORMULA (#200901)
1 Vegetarian Capsule Contains:
Vitamin D-3………………………………….1000
MERIVA® Curcumin Phytosome ..................250 mg
(Curcuma longa extract,
rhizome)/Phosphatidycholine (soy) complex)
Resveratrol (as trans-resveratrol) ...................100 mg
Pterostilbene (pTeroPure™).............................50 mg
Proprietary Cruciferous ..................................150 mg
Vegetable and Fruit Blend:
Wasabia japonica (rhizome, providing 600 mcg
total glucosinolates), Broccoli powder (sprout)
(BroccoPhane™) (standardized to contain 200 mcg
of sulforaphane) and Organic Pomegranate powder
Other ingredients: Cellulose (capsule), calcium citrate,
microcrystalline cellulose, vegetable stearate, silica and titanium
Meriva® is a registered trademark of Indena S.p.A, Milano.
is a trademark of ChromaDex, Inc.
is a registered trademark of DSM
Adults take 1 capsule daily with meals or as
directed by your healthcare professional.
No adverse side effects reported.
Store in a cool, dry place, away from direct
light. Keep out of reach of children.
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