Co-Enzyme Q10

100 mg Softgels with Vitamin E
Co-Enzyme Q10 softgels, provided by Douglas
Laboratories, contain pure co-enzyme Q10
(ubiquinone). Co-enzyme Q10 is solubilized in a
base of rice bran oil and vitamin E to enhance
absorption of co-enzyme Q10.
Co-Enzyme Q10 (ubiquinone) is an important ratelimiting
cofactor in the mitochondrial electron
transport chain, the biochemical pathway in cellular
respiration from which adenosine triphosphate
(ATP), the form of energy used by the body, is
derived. Since cellular activities are dependent upon
energy, co-enzyme Q10 is crucial for the efficient
functioning of nearly every cell.
In addition to its well-established function as a
component of the mitochondrial electron transport
chain, co-enzyme Q10 has in recent years acquired
increasing attention regarding its antioxidant
properties. Co-Enzyme Q10 occurs in all cellular
membranes as well as in blood serum and in serum
lipoproteins. As a lipid-soluble antioxidant, coenzyme
Q10 efficiently protects membrane
phospholipids and serum low-density lipoproteins
from lipid peroxidation. And, as recent data indicate,
it also protects mitochondrial membrane proteins and
DNA from free radical induced oxidative damage.
These effects of co-enzyme Q10 are independent of
those of other antioxidants, such as vitamin E;
although co-enzyme Q10 can also extend the
functions of vitamin E by regenerating
it from its oxidized form. Tissue co-enzyme Q10
levels are regulated through the mevalonate pathway,
increasing with various forms of oxidative stress, and
decreasing during aging. Related to its antioxidant
properties, co-enzyme Q10 is important for normal
immune function. This has been shown in a number
of experimental and clinical studies.
Healthy people have the ability to synthesize adequate
amounts of co-enzyme Q10. According to Dr. Karl
Folkers and other researchers, humans can synthesize
co-enzyme Q10 from the amino acids tyrosine or
phenylalanine and mevalonic acid, all of which are
abundant in the body. However, the synthesis is a
complex process involving 15 separate steps which
require many enzymes, nutritional mineral cofactors,
and vitamin coenzymes.
As a result, the biosynthesis of co-enzyme Q10 in the
human body requires a good diet – one that is high in
vitamins, minerals, and other nutrient factors. Yet, it
has been shown by NHANES I and II studies that
many Americans do not consume an adequate diet.
Rather, for many, dietary intake of water soluble
vitamins, vitamin A, and some minerals and trace
elements is insufficient. Many of these nutrients are
essential for the biosynthesis of co-enzyme Q10.
Thus, it is not surprising that the nutritional status of
co-enzyme Q10 tends to decline with advancing age.
In addition, it has been shown that in disease states,
nutrients from food sources may not be readily
absorbed or bioavailable. According to Folkers and
other experts, co-enzyme Q10 should be considered an
essential nutrient, as it is well established that coenzyme
Q10 is essential for the health of every cell in
the human body.
Co-Enzyme Q10 softgels may be a useful dietary
supplement for those who wish to support their
body’s own production of co-enzyme Q10.
Each softgel contains:
Co-Enzyme Q10 (ubiquinone) .................100mg
Vitamin E (d-alpha tocopherol) .............100I.U.
One to two softgels daily as a dietary supplement or
as directed by a physician.
No adverse effects have been reported.
Douglas Product Data
(continued on reverse)
Store in a cool, dry place, away from direct light.
Keep out of reach of children.
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These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.