Wobenzym® PS

Professional Strength Systemic Enzymes
for Immune and Joint Support

Douglas Laboratories, a leading provider of dietary
supplements, is proud to offer its newest systemic
enzyme supplement, Wobenzym PS. This product
contains the authentic German Phlogenzym
formula used by health professionals in Europe.
Wobenzym PS is clinically supported to help
maintain healthy joint function† and is exclusively
available to healthcare professionals.
Wobenzym PS is offered in the form of entericcoated
tablets and provides a specific
formulation of enzymes to the body to help
maintain optimal immune function, and wound
healing as well as muscle and tendon structure.†
For over 60 years, Wobenzym® has been a trusted
name for systemic enzyme supplementation.
Developed by leading scientists and used by
millions of people worldwide, the family of
Wobenzym® products has proven to be safe and
useful for overall immune support. Wobenzym PS in
particular has numerous clinical studies that link its
use to maintaining optimal joint health.
In the human body, hundreds of chemical
reactions occur during the course of normal
metabolic processes. Many chemical reactions
require significant energy in order to take place,
and therefore need a catalyst to allow the
reaction to proceed. The catalyst acts to lower
the energy needed for the reaction to move
forward. In the body, enzymes play the role of
the catalyst and allow reactions to take place
that otherwise would not occur. The enzyme
itself is not consumed in this process and can be
utilized again and again. Enzymes are relatively
unique to each reaction and different enzymes
will catalyze different reactions. Structurally,
enzymes are complex molecules that are
comprised of amino acid chains and can
sometimes include co-factors which assist the
enzyme in the chemical reaction. Some
enzymes are sensitive to changes in pH and
temperature and can be destroyed if exposed to
less than ideal conditions.
Wobenzym® PS is a systemic enzyme formulation
that contains a unique blend of enzymes from both
plants and animals that haves been clinically
studied for supporting numerous processes in the
body.† Systemic enzyme supplements work directly
in the body after they are absorbed in the small
intestine, and are not intended to aid in digestion.
Consequently, these enzymes can be utilized to
assist the body’s various regulatory and
communications systems.†
After the enzymes are absorbed, protease
molecules can bind with molecules found within
the blood including 􀀀 -2-macroglobulin, resulting
in the formulation of an 􀀀-2-macroglobulinprotease
complex. This newly formed complex
alters the molecular configuration of the 􀀀-2-
macroglobulin molecule which results in a
change in its affinity to bind certain cytokines.
Once a cytokine is bound to the protease, the
entire complex is able to be eliminated from the
body, allowing normal cytokine balance and
immune function to be maintained (Figures 1
and 2).
Wobenzym® PS can help to support healthy joints
and muscles, and support the immune system as
well as normal wound healing processes†.
Figure 1
Figure 2
Wobenzym® PS tablets are enteric coated to ensure
that the enzymes are protected and are not broken
down in the stomach. This allows the enzymes to
reach the small intestine where absorption can
Wobenzym® PS may be a useful dietary
supplement for individuals wishing to support
healthy joint, immune and circulatory function.
FORMULA (200870)
3 Enteric Coated Tablets Contain:
Bromelain 1350 FIP unit* .................... 270 mg
Ananas comosus
Rutoside trihydrate (Rutin) .................. 300 mg
Sophora japonica
Trypsin 4320 FIP unit* ........................ 144 mg
(pancreas) Sus scrofa
Other ingredients: microcrystalline cellulose,
calcium phosphate, hydroxypropyl cellulose,
vegetable stearate, vegetable-based pH
resistant enteric coating, silica, natural vanilla
flavor and purified water.
* FIP is the measurement of enzyme activity according to the
methods of the Internationale Phamaceutique Federation.
Adults take 3 tablets 2 times daily at least 45
minutes before meals or as directed by your
healthcare professional.
Warning: If you are pregnant or breastfeeding,
suffering from bleeding disorders or liver damage,
or if you are taking anticoagulant drugs (such as
warfarin), consult a healthcare professional before
using this product.
Store in a cool, dry place, away from direct light.
Keep out of reach of children.
Biziulevicius GA. Where do the immunostimulatory effects of
oral proteolytic enzymes ('systemic enzyme therapy') come
from? Microbial proteolysis as a possible starting point. Med
Hypotheses. 2006;67(6):1386-8.
Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and
tolerance of an oral enzyme combination in painful
osteoarthritis of the hip. A double-blind, randomised study
comparing oral enzymes with non-steroidal anti-inflammatory
drugs. Clin Exp Rheumatol. 2006 Jan-Feb;24(1):25-30.
Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral
enzyme combination versus diclofenac in the treatment of
osteoarthritis of the knee--a double-blind prospective
randomized study. Clin Rheumatol. 2004 Oct;23(5):410-5.
Kamenícek V, Holán P, Fran􀀀k P. [Systemic enzyme
therapy in the treatment and prevention of post-traumatic
and postoperative swelling] [Article in Czech] Acta Chir
Orthop Traumatol Cech. 2001;68(1):45-9.
Shahid SK, Turakhia NH, Kundra M, Shanbag P, Daftary
GV, Schiess W. Efficacy and safety of phlogenzym--a
protease formulation, in sepsis in children. J Assoc
Physicians India. 2002 Apr;50:527-31.
Singer F; Singer C ;Oberleitner H. Phlogenzym® versus
diclofenac in the treatment of activated osteoarthritis of the
knee. A double-blind prospective randomized study.
International Journal of Immunotherapy.2001:17,(2-4): 135-
Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W.
Efficacy and tolerability of oral enzyme therapy as compared
to diclofenac in active osteoarthrosis of knee joint: an open
randomized controlled clinical trial. J Assoc Physicians India.
2001 Jun;49:617-21.
Wittenborg A, Bock PR, Hanisch J, Saller R, Schneider B.
[Comparative epidemiological study in patients with
rheumatic diseases illustrated in a example of a treatment
with non-steroidal anti- inflammatory drugs versus an oral
enzyme combination preparation] [Article in German]
Arzneimittelforschung. 2000 Aug;50(8):728-38
†These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.