Co-Enzyme Q10


100 mg Softgels with Vitamin E
DESCRIPTION
Co-Enzyme Q10 softgels, provided by Douglas
Laboratories, contain pure co-enzyme Q10
(ubiquinone). Co-enzyme Q10 is solubilized in a
base of rice bran oil and vitamin E to enhance
absorption of co-enzyme Q10.
FUNCTIONS
Co-Enzyme Q10 (ubiquinone) is an important ratelimiting
cofactor in the mitochondrial electron
transport chain, the biochemical pathway in cellular
respiration from which adenosine triphosphate
(ATP), the form of energy used by the body, is
derived. Since cellular activities are dependent upon
energy, co-enzyme Q10 is crucial for the efficient
functioning of nearly every cell.
In addition to its well-established function as a
component of the mitochondrial electron transport
chain, co-enzyme Q10 has in recent years acquired
increasing attention regarding its antioxidant
properties. Co-Enzyme Q10 occurs in all cellular
membranes as well as in blood serum and in serum
lipoproteins. As a lipid-soluble antioxidant, coenzyme
Q10 efficiently protects membrane
phospholipids and serum low-density lipoproteins
from lipid peroxidation. And, as recent data indicate,
it also protects mitochondrial membrane proteins and
DNA from free radical induced oxidative damage.
These effects of co-enzyme Q10 are independent of
those of other antioxidants, such as vitamin E;
although co-enzyme Q10 can also extend the
functions of vitamin E by regenerating
it from its oxidized form. Tissue co-enzyme Q10
levels are regulated through the mevalonate pathway,
increasing with various forms of oxidative stress, and
decreasing during aging. Related to its antioxidant
properties, co-enzyme Q10 is important for normal
immune function. This has been shown in a number
of experimental and clinical studies.
Healthy people have the ability to synthesize adequate
amounts of co-enzyme Q10. According to Dr. Karl
Folkers and other researchers, humans can synthesize
co-enzyme Q10 from the amino acids tyrosine or
phenylalanine and mevalonic acid, all of which are
abundant in the body. However, the synthesis is a
complex process involving 15 separate steps which
require many enzymes, nutritional mineral cofactors,
and vitamin coenzymes.
As a result, the biosynthesis of co-enzyme Q10 in the
human body requires a good diet – one that is high in
vitamins, minerals, and other nutrient factors. Yet, it
has been shown by NHANES I and II studies that
many Americans do not consume an adequate diet.
Rather, for many, dietary intake of water soluble
vitamins, vitamin A, and some minerals and trace
elements is insufficient. Many of these nutrients are
essential for the biosynthesis of co-enzyme Q10.
Thus, it is not surprising that the nutritional status of
co-enzyme Q10 tends to decline with advancing age.
In addition, it has been shown that in disease states,
nutrients from food sources may not be readily
absorbed or bioavailable. According to Folkers and
other experts, co-enzyme Q10 should be considered an
essential nutrient, as it is well established that coenzyme
Q10 is essential for the health of every cell in
the human body.
INDICATIONS
Co-Enzyme Q10 softgels may be a useful dietary
supplement for those who wish to support their
body’s own production of co-enzyme Q10.
FORMULA (CQS1)
Each softgel contains:
Co-Enzyme Q10 (ubiquinone) .................100mg
Vitamin E (d-alpha tocopherol) .............100I.U.
SUGGESTED USE
One to two softgels daily as a dietary supplement or
as directed by a physician.
SIDE EFFECTS
No adverse effects have been reported.
Douglas Product Data
Laboratories®
(continued on reverse)
STORAGE
Store in a cool, dry place, away from direct light.
Keep out of reach of children.
REFERENCES
Alleva R, Tomasetti M, Battino M, Curatola G, Littarru GP, Folkers K.
The roles of coenzyme Q10 and vitamin E on the peroxidation of human
low density lipoprotein subfractions. Proc Natl Acad Sci USA
1995;92:9388-9391.
Amimoto T, Matsura T, Koyama S-Y, Nakanishi T, Yamada K,
Kajiyama G. Acetaminophen-induced hepatic injury in mice: The role
of lipid peroxidation and effects of pretreatment with coenzyme Q10
and a-tocopherol. Free Radic Biol Med 1995;19:169-176.
Beyer RE. The role of ascorbate in antioxidant protection of
biomembranes: Interaction with vitamin E and coenzyme Q. J
Bioenerg Biomembr 1994;26:349-358.
Bliznakov EG. Coenzyme Q, the immune system and aging. In:
Biochemical and Clinical Aspects of Coenzyme Q10, Vol 3, Folkers K
and Yamamura Y Eds., Elsevier Science Publishers, 1981, pp.331-326.
Chen H, Tappel AL. Vitamin E, selenium, trolox C, ascorbic acid
palmitate, acetylcysteine, coenzyme Q, b-carotene, canthaxanthin, and
(+)-catechin protect against oxidative damage to kidney, heart, lung
and spleen. Free Radic Res 1995;22:177-186.
Ernster L, Dallner G. Biochemical, physiological and medical aspects
of ubiquinone function. Biochim Biophys Acta Mol Basis Dis
1995;1271:195-204.
Folkers K, Littarru GP, Yamagami Y, Eds. Biochemical and Clinical
Aspects of Coenzyme Q10, Vol 6, Elsevier Science Publishers, 1991.
Folkers K, Morita M, McRee J, Jr. The activities of coenzyme Q10 and
vitamin B6 for immune responses. Biochem Biophys Res Commun
1993;193:88-92.
Folkers K, Simonsen R. Two successful double-blind trials with
coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic
atrophies. Biochim Biophys Acta Mol Basis Dis 1995;1271:281-286.
Greenberg S, Frishman WH: Coenzyme Q10: a new drug for
cardiovascular disease. J Clin Pharm 1990;30:596-608.
Kamikawa T, Kobayashi A. Effects of coenzyme Q10 on exercise
tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-
251.
Kontush A, Hübner C, Finckh B, Kohlschütter A, Beisiegel U.
Antioxidative activity of ubiquinol-10 at physiologic concentrations in
human low density lipoprotein. Biochim Biophys Acta Lipids Lipid
Metab 1995;1258:177-187.
Langsjoen PH et al. Long-term safety and efficacy of coenzyme Q10
therapy for idiopathic dilated cardiomyopathy. Am J Cardiol
1990;65:521-523.
Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on
therapy of breast cancer with vitamin Q10 and the regression of
metastases. Biochem Biophys Res Commun 1995;212:172-177.
Maurer I et al. Coenzyme Q10 and respiratory chain enzyme activities
in hypertrophied human left ventricles with aortic stenosis. Am J
Cardiol 1990;66:504-505.
Morita K, Ihnken K, Buckberg GD, Young HH. Studies of
hypoxemic/reoxygenation injury: Without aortic clamping. VII.
Counteraction of oxidant damage by exogenous antioxidants:
Coenzyme Q10. J Thorac Cardiovasc Surg 1995;110:1221-1227.
Mortensen SA et al. Deficiency of coenzyme Q10 in myocardial failure.
Drugs Exp Clin Res 1985;10:497-502.
Nakamura R et al. Study of CoQ10 enzymes in gingiva from patients
with periodontal disease and evidence for a deficiency of coenzyme
Q10. Prc Natl Acad Sci 1974;71:4156-4160.
Stoyanovsky DA, Osipov AN, Quinn PJ, Kagan VE. Ubiquinonedependent
recycling of vitamin E radicals by superoxide. Arch
Biochem Biophys 1995;323:343-351..
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.