Methylcobalamin Liquid
High Potency Vitamin B12


DESCRIPTION
Methylcobalamin Liquid, provided by Douglas
Laboratories®, provides 1,000 mcg of highly
bioavailable vitamin B12 in a tasty and convenient
liquid.
FUNCTIONS
Vitamin B12 is essential for normal metabolism of
carbohydrates, fat and protein. As a cofactor for
methylmalonyl-CoA mutase enzymes, vitamin B12
helps convert odd chain fatty acids and branched
chain amino acids into succinyl-CoA, a common
citric acid cycle intermediate. Vitamin B12 is also
required for nucleic acid (DNA) synthesis,
methionine synthesis from cysteine, and normal
myelin synthesis in the nervous system. Along with
vitamin B6 and folic acid, adequate levels of vitamin
B12 are required to maintain normal plasma
homocysteine levels. Certain populations, including
the elderly, those with HIV/AIDS, and strict
vegetarians are often at risk for vitamin B12
deficiency, either due to low dietary intake or
impaired absorption.
Most of the vitamin B12 found in supplements is in
the form of cyanocobalamin. While cyanocobalamin
is an excellent source of vitamin B12, studies indicate
that methylcobalamin, a coenzyme form of B12, may
be better utilized and better retained in the body.
Other studies indicate that methylcobalamin itself
may play important roles in supporting neurological
and immune health.
INDICATIONS
Methylcobalamin Liquid may be a useful nutritional
adjunct for individuals who wish to increase their
intake of vitamin B12.
FORMULA (#200159)
1 dropper (1 ml) contains
Vitamin B12 ....................................................................... 1,000 mcg
(methylcobalamin)
Other ingredients: Purified water, natural glycerin,
sodium benzoate, natural cherry flavor
SUGGESTED USE
Adults take 1 dropper (1 ml) daily or as directed by
your healthcare professional.
SIDE EFFECTS
No adverse side effects reported.
STORAGE
Store in a cool, dry place, away from direct light.
Keep out of reach of children and refrigerate.
REFERENCES
Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A
quantitative assessment of plasma homocysteine as a risk factor for
vascular disease - Probable benefits of increasing folic acid intakes.
JAMA 1995;274:1049-1057.
Curtis D, Sparrow R, Brennan L, Van Der Weyden MB. Elevated
serum homocysteine as a predictor for vitamin B12 or folate
deficiency. Eur J Haematol 1994;52:227-232.
Ehrenpreis ED, Carlson SJ, Boorstein HL, Craig RM. Malabsorption
and deficiency of vitamin B12 in HIV-infected patients with chronic
diarrhea. Dig Dis Sci 1994;39:2159-2162.
Flynn MA, Irvin W, Krause G. The effect of folate and cobalamin on
osteoarthritic hands. J Am Coll Nutr 1994;13:351-356.
Harriman GR, Smith PD, Horne MK, et al. Vitamin B12
malabsorption in patients with acquired immunodeficiency
syndrome. Arch Intern Med 1989;149:2039-2041.
Jalaludin MA. Methylcobalamin treatment of Bell's palsy. Methods
Find Exp Clin Pharmacol. 1995 Oct;17(8):539-44.
Nishizawa Y, Yamamoto T, Terada N, Fushiki S, Matsumoto K,
Nishizawa Y. Effects of methylcobalamin on the proliferation of
androgen-sensitive or estrogen-sensitive malignant cells in culture
and in vivo. Int J Vitam Nutr Res. 1997;67(3):164-70.
Rauma AL, Törrönen R, Hänninen O, Mykkänen H. Vitamin B-12
status of long-term adherents of a strict uncooked vegan diet ("living
food diet") is compromised. J Nutr 1995;125:2511-2515.
Saltzman JR, Kemp JA, Golner BB, Pedrosa MC, Dallal GE, Russell
RM. Effect of hypochlorhydria due to omeprazole treatment or
atrophic gastritis on protein-bound vitamin B12 absorption. J Am Coll
Nutr 1994;13:584-
Douglas
Laboratories®